Foundation Principles

4P medicine

Our vision of medicine is predictive, preventive, personalized and participatory (4P). This approach has long since been advocated for by pioneers in medicine, but unfortunately, today’s medicine is still far from this vision. According to the principles of 4P medicine, the best way to keep people healthy is to predict the individual’s risks and the subsequent prevention of the progression of these risks into their associated diseases. This can be achieved best through personalized intervention, which can occur only through the active participation of the affected individual.

High-definition medicine

High-definition medicine is the new era of data-driven medicine, which is based on the technological advancements in biology and engineering, enabling examinations like genome sequencing, whole-body MRI, wearable biosensors and many more. As these novel methods became readily available, so did the possibility to assess an individual’s current health status and disease risks with a previously unprecedented precision. These examinations also enable the determination of a strong health baseline, by which deviations detected during subsequent screening can identify early stage diseases, making timely intervention possible.

Comprehensive Examinations

Based on your gender, age, medical history and current complaints, we prepare a personalized set of medical examinations for you and combine this with a set of OMICS measurements. The medical examinations include: a complete physical examination; the most advanced techniques in medical imaging, such as coronary CT and whole-body MRI; functional tests such as spirometry; and a thorough laboratory test, with over 450 examined parameters.

Report and Health Coaching

Connecting the dots

Following the completion your examinations, Medipredict analyzes your data and integrates multi-disciplinary knowledge with curated databases in order to uncover the hidden connections within your results.

Integrated medical report

Our report is a comprehensive overview of your current health status and potential disease risks. In this document, we present your results with emphasis on the important and actionable findings organized around your organ systems and detected risks in order to help you visualize the complete picture. Although the integrated medical report includes explanations, a Medipredict medical doctor and health-coach will help you by explaining and interpreting your results, and by identifying the actionable findings. All your raw data and our conclusions will be accessible in our online system as well.

Personalized health-coaching and follow-up

After the initial report consultation, Medipredict will provide you regular consultations with our health-coach to help you adapt to your new lifestyle. We will follow-up on your health status and offer additional examinations which are tailored to your personal needs. If we happen to find any developing condition which fulfills the diagnostic criteria of a disease, we will direct you to the right physician and help you manage your condition.

Mixed - Omics Measurements

The so called -omics measurements aim not at measuring one or a couple of variables, but rather, the full collection of variables in a system. Following, the full complement of genes is the genome, all the transcripts that are transcribed from the genome are referred to as the transcriptome, all proteins that are produced from these transcripts the proteome, and all metabolites in a biological system the metabolome. In addition, sequencing technology has also made it possible to get an overview of the complement of microorganisms - the microbiome - in a specific sample, such as feces or skin. For the interpretation of this data we use internal databases that are constructed through literature knowledge from our internal expertise. Furthermore, we use data integration and machine learning approaches to identify new associations with diseases and the other -omics measurements.

Whole genome sequencing (WGS)

Genomics is a modern field of molecular biology which studies the entire genome or the complete DNA sequence of an organism. Your genetic code is written with 4 bases: guanine, cytosine, adenine and thymidine which are represented by the letters G, C, A, T. The sequence of these bases in the human DNA has been determined in a handful of people by the Human Genome Project and a so called “human reference genome” was assembled. Comparing a person’s DNA sequence to the human reference genome can identify DNA variations that differ from the reference and pose a possible genetic risk for developing certain diseases. Medipredict enlists whole genome sequencing (WGS) to analyze your entire DNA and screens for single-nucleotide variations (SNVs), small insertions, deletions (indels) and copy number variations (CNVs) that may influence your health. Additionally, we take an integrative approach and look at WGS data in the context of other datasets to determine whether outliers can be explained by your genetic composition. For example, if we observe elevated cholesterol levels in the metabolic profile, we will screen the genome for variants that may influence lipoprotein metabolism.

Serum metabolomics

Metabolomics is the scientific discipline that aims at comprehensively mapping the chemical variation in a biological sample. As such, it determines the levels of small molecules that are the direct product of metabolism. Medipredict uses state-of-the-art mass-spectrometry based measurements of >500 biochemicals in serum and compares these levels with those of a reference population of >300 people. For data interpretation, we look at those metabolites that deviate from the reference population and query our internal databases whether these metabolites have been linked to disease. For instance, elevated levels of the metabolite trimethylamine-N-oxide (TMAO) is a risk factor for cardiovascular disease. Interestingly, TMAO is the oxidation product of trimethylamine which is produced in the gut by specific bacteria.

Gut microbiome analysis

It has become clear that our body is not only composed of our own cells, but that humans closely associate with highly specialized communities of microorganisms consisting of fungi, viruses, archaea and bacteria. The vast majority of these microorganisms are friendly commensals that help us with important tasks such as production of vitamins, digestion of food, protection against infections, and training of our immune system. The densest community of microorganisms is that of the large intestine, and is referred to as the gut microbiome. Microbial diversity and composition of the gut microbiome have been associated with many diseases, and loss of specific bacterial triggers at the right point in time could be responsible for many of the so called "Western diseases," such as allergies, chronic inflammation, autoimmune diseases, and some neurological disorders such as Alzheimer’s disease and autism. The gut microbiome is not an established diagnostic tool and there still exist a multitude of unanswered questions. We have taken a critical look at the literature and composed a database of gut microbiome - health associations we believe could be relevant now. In addition, we look at metabolite - bacteria interactions such as high oxalate levels in blood; a risk factor for kidney stones, and the presence of oxalate-consuming Oxalobacter.

Wide range of blood panels

We measure more than 450 laboratory parameters to map the function of every organ system, from allergies to inflammatory factors to hormone panels, we measure them all. Our medical and omics team put together the protocol of the laboratory tests which include stool, urine, sperm and blood sample analysis. Both the extended medical protocols and the latest research results were taken into consideration when the final content of each panel was concluded. These specific blood panels and the urinalysis cover ions, total blood count and hematologic status, liver function, kidney function, blood coagulation, infections and vaccination, gastrointestinal function, immune function and autoimmune disease screening, inflammatory factors, hormone levels, inhaled allergy panel, oral glucose tolerance test and diabetes screening, lipid levels, food sensitivity, leaky gut signs, coeliac disease screening, tumor markers and women’s health. The stool sample analysis can reveal inflammatory bowel disease signs. The sperm sample analysis can detect possible infertility.

Full-scale imaging

The whole-body MRI examination is the most comprehensive, yet noninvasive medical imaging method that gives an accurate snapshot of each organs’ internal structure. For example, with the interpretation of these scans, it is possible to assess the state of the musculoskeletal system, hence diseases such as the degeneration of the intervertebral discs can be detected even before the emergence of clinical symptoms, thus by timely intervention the progression of such disease can be halted. It is also possible to detect certain tumors, to accurately measure body composition in respect to fat and muscle volume, to examine the vascular and neural structure of the brain, and many more. Medipredict uses low-dose chest CT scan to detect early stage lesions or other structural alterations of the lunge. CT is also used to comprehensively assess the state of the coronaries. In order to do so, the combination of a non-contrast scan and a contrast coronarography is used to detect both calcified and noncalcified plaques of the coronary vessels that can lead to coronary heart disease. Ultrasonography provides real-time structural and functional information of the examined soft tissues. This method enables the accurate measurement of blood flow as well, which gives valuable functional informations of the state of the cardiovascular system.

Specialized wearables

Wearable fitness and medical devices enable the tracking of multiple physiological parameters of various organ systems such as the cardiovascular, respiratory and nervous systems. Continuous recording of the heart rate, ECG and saturation enables the early detection of arrhythmias, and the comprehensive assessment of the cardiovascular systems adaptability towards certain levels of activity. Combining this information with respiration and movement data enables the accurate estimation of physical activity and burned calories. Tracking sleep with wearables or smart mats can lead to the diagnosis of obstructive sleep apnea, restless leg syndrome or other diseases. By analyzing long term sleep quality data certain lifestyle patterns can be identified that lead to poor sleep. Changing these could result a better sleep hygiene. Digital medical devices such as blood pressure or blood glucose monitors are also representing a valuable data source. The original offline/analogous versions of these devices could provide valuable information but without automatic synchronization frequently gets lost and remains dark data. This synchronization capability of these novel devices make it possible to frequently register information during a long timeframe which enables detecting trends in the changes of the recorded parameters such as stress related high blood pressure.